A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Human Rad51 filaments on double- and one-stranded DNA: correlating normal and irregular sorts with recombination perform.
[Laughs] ‘It had been undoubtedly a fantastic threat! At time, I was nicely conscious that it could go Incorrect Which I could develop into a lot less profitable, but I just dismissed that. Curiosity has usually been my strongest driving force. And fortunately all of it worked out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. In just just a few months, we were in the position to measure transportation by way of an individual solitary-walled carbon nanotube. According to low-temperature experiments by an excellent PhD student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Lively study lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes had been authentic quantum wires with extremely extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
What distinguishes biology from chemistry is always that these factors together make up a living program. The key of claimed everyday living, I think, lies inside the interactions, the interplay of People molecules. The massive dilemma regarding the origin of daily life remains to be unanswered. How did we at any time evolve from uncomplicated molecules into your extremely complicated methods we see right now? We don't know. I would like to operate on these kinds of massive, open up inquiries.’
Nanopores stand for a chic and flexible tool to measure single molecules. We analysis novel detection modes with solid-condition nanopores in addition to many solutions to measure proteins with nanopores. Tasks encompass the subsequent:
‘You should not just consider the concerns of tomorrow, but will also look at cees dekker the inquiries in the working day immediately after tomorrow’
Dekker commenced his study on solitary carbon nanotubes in 1993 when he set up a whole new line of research to review electrical transportation via solitary natural and organic molecules among nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was accomplished in a very collaboration With all the team of Nobel laureate Richard Smalley. STM and nanolithography techniques have been utilized to demonstrate that these nanotubes are quantum wires at The only-molecule stage, with outstanding physical Houses.
Because 2000 he moved to one-molecule biophysics and nanobiology, with research from reports of DNA loop extrusion and supercoiling to DNA translocation through nanopores. A lot more a short while ago his analysis has centered on researching chromatin structure and cell division with microbes on chip, whilst he can be seeking to ultimately Create artificial cells from The underside up.
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It was an exceptionally interesting time, during which I acquired many assistance from Delft University of Technological know-how, where by I had been a professor at time, And that i started off many collaborations with molecular biologists. That aided me master lots.’